pentobarbital will lessen the level or effect of sufentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
pentobarbital will minimize the level or influence of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Long-time period coadministration of strong CYP3A4 inducers with rolapitant may well significantly decrease rolapitant efficacy.
If unable to avoid, double latest pralsetinib dose starting up on Day seven of coadministration with sturdy CYP3A inducer. Soon after inducer has become discontinued for at least 14 times, resume previous pralsetinib dose.
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pentobarbital will decrease the level or influence of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the level or impact of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
Contraindicated (1)pentobarbital will lower the extent or outcome of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the extent or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Pitolisant publicity is diminished by fifty% if coadministered with robust CYP3A4 inducers.
pentobarbital will lower the extent or result of irinotecan liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the extent or outcome of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If not able to keep away from coadministration of stiripentol with sturdy CYP3A4 inducers, boost stiripentol dose.
Monitor Intently (1)pentobarbital will lessen the extent or outcome of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Reserve concomitant prescribing of such prescription drugs in people for whom other treatment options are insufficient. Restrict dosages and durations into the minimum amount demanded. Observe intently for signs of respiratory melancholy and sedation.
fentanyl intranasal and pentobarbital both of those raise sedation. Stay away from or Use Alternate Drug. Restrict use to people for whom option treatment alternatives are here inadequate
pentobarbital will lessen the extent or impact of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.